Mount Sinai Health System has partnered with OpenEvidence to embed its AI-powered medical search and clinical decision-support platform directly into the Epic electronic health record (EHR) system. This first enterprise-scale deployment will give physicians, nurses, and pharmacists seamless access to trusted, evidence-based answers drawn from peer-reviewed literature and clinical guidelines during daily workflows.
Glimpse:
Announced on March 31, 2026, the collaboration extends OpenEvidence across Mount Sinai’s seven-hospital network and academic institutions, reaching nearly 50,000 clinical staff members. Clinicians can ask natural language questions within the Epic system and receive immediate, cited responses grounded in reliable medical sources. The initiative aims to reduce information overload, support better decision-making, and set a new standard for safe, equitable AI use in clinical care.
Mount Sinai Health System, one of the largest academic medical networks in the United States, has entered into a strategic collaboration with OpenEvidence to bring advanced AI capabilities directly into its clinical environment. The partnership integrates OpenEvidence’s platform into the existing Epic electronic health record system used across the organization’s seven hospitals, the Icahn School of Medicine at Mount Sinai, and the Mount Sinai Phillips School of Nursing. This marks the first large-scale enterprise deployment of the AI tool, making it available to the entire care team including physicians, registered nurses, and pharmacists.
With this integration, healthcare professionals can pose medical questions in everyday language and instantly receive accurate, evidence-based responses sourced exclusively from peer-reviewed literature and established clinical guidelines. The system is designed to operate seamlessly within the normal Epic workflow, allowing staff to access critical information without leaving the patient record. By embedding the tool at the point of care, Mount Sinai aims to lighten the cognitive load on busy clinicians, minimize time spent searching for reliable data, and ultimately improve the quality and safety of patient care.
Mount Sinai has long been at the forefront of artificial intelligence adoption in healthcare. The health system established the Windreich Department of AI and Human Health and recently opened the Hamilton and Amabel James Center for Artificial Intelligence and Human Health on its Manhattan campus. This new collaboration with OpenEvidence builds on that leadership by extending trusted AI support beyond physicians to all members of the care team, promoting more equitable access to the latest medical evidence.
OpenEvidence functions as a governed medical search engine that prioritizes transparency and reliability. Every response includes citations, helping clinicians verify information quickly and reducing risks often associated with generative AI tools. The deployment is expected to enhance decision-making processes across various roles and support Mount Sinai’s commitment to delivering high-quality, evidence-driven care in a complex academic medical setting.
“Our partnership with OpenEvidence is a vital step in democratizing access to the latest clinical evidence for every member of the Mount Sinai care team. We are committed to equipping our clinicians with intuitive, AI-powered tools that reduce the cognitive burden of information retrieval and allow them to focus on what matters most the patient.”
By
HB Team
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